The Mercedes-Benz S-Class, formerly known as Sonderklasse (German for "special class", abbreviated as "S-Klasse"), is a series of full-sized luxury flagship vehicles produced by the German automaker Mercedes-Benz, a division of German company Daimler AG. The S-Class designation for top-of-the-line Mercedes-Benz models was officially introduced in 1972 with the W116, and has remained in use ever since.

The S-Class has debuted many of the company's latest innovations, including drivetrain technologies, interior features, and safety systems (such as the first seatbelt pretensioners). The S-Class has ranked as the world's best-selling luxury sedan,and its latest generation, the W222 S-Class, premiered in 2013. As in previous iterations, the W222 S-Class is sold in standard and long-wheelbase versions; I4, V6, V8, V12, diesel and hybrid powertrains are offered. All models built in Mexico or sold in the United States are available in long wheelbase only.